Table 1.
Characteristics of ART in Japan from 2007 to 2010
| 2007 | 2008 | 2009 | 2010 | |
|---|---|---|---|---|
| Number of ART clinics | 606 | 609 | 625 | 591 |
| Submitted data | 603(99.5 %) | 603(99.0 %) | 622(99.5 %) | 587(99.3 %) |
| Number of ART cycles | ||||
| Fresh | 115,686 | 130,498 | 139,873 | 158,391 |
| Frozen | 45,478 | 60,115 | 73,927 | 83,770 |
| Total | 161,164 | 190,613 | 213,800 | 242,161 |
| Fertilization procedure in fresh cycle | ||||
| IVF-ET | 52,477 | 57,719 | 61,366 | 65,239 |
| ICSI | 61,813 | 71,350 | 76,790 | 90,677 |
| Othersa | 1,396 | 1,429 | 1,717 | 2,475 |
| Total | 115,686 | 130,498 | 139,873 | 158,391 |
| Number of retrieval | ||||
| 112,459 | 127,081 | 136,094 | 153,788 | |
| Number of embryo transfer | ||||
| Fresh | 62,260 | 63,549 | 63,726 | 65,077 |
| Frozen | 43,589 | 57,846 | 71,367 | 81,300 |
| Total | 105,849 | 121,395 | 135,093 | 146,377 |
| Number of SET and SET rate | ||||
| Fresh | 28,968(46.5 %) | 38,048 (59.9 %) | 42,913(67.3 %) | 45,522(70.0 %) |
| Frozen | 23,845(54.7 %) | 39,155(67.7 %) | 52,464(73.5 %) | 61,308(75.4 %) |
| Total | 52,813(49.9 %) | 77,203(63.6 %) | 95,377(70.6 %) | 106,830(73.0 %) |
| Number of pregnancy | ||||
| Fresh | 15,200 | 13,914 | 14,221 | 14,255 |
| Frozen | 13,965 | 18,597 | 23,216 | 27,382 |
| Pregnancy rate (Per ET) | ||||
| Fresh (IVF-ET) | 26.4 % | 23.8 % | 24.3 % | 23.7 % |
| Fresh (ICSI) | 22.9 % | 20.4 % | 20.8 % | 20.7 % |
| Fresh total | 24.4 % | 21.9 % | 22.3 % | 21.9 % |
| FER | 32.0 % | 32.1 % | 32.5 % | 33.7 % |
| Pregnancy rate in fresh cycle (Per retrieval) | ||||
| IVF-ET | 14.4 % | 12.2 % | 11.5 % | 10.4 % |
| ICSI | 12.9 % | 10.0 % | 9.7 % | 8.7 % |
| Number of miscarriage | ||||
| Fresh | 3,611 | 3,372 | 3,508 | 3,575 |
| Frozen | 3,501 | 4,605 | 5,876 | 6,998 |
| Miscarriage Rate (per pregnancy) | ||||
| Fresh (IVF-ET) | 23.2 % | 23.1 % | 23.6 % | 23.9 % |
| Fresh (ICSI) | 24.2 % | 25.2 % | 25.6 % | 26.0 % |
| FER | 25.1 % | 24.8 % | 25.3 % | 25.6 % |
| Number of live-birth | ||||
| Fresh | 9,206 | 8,665 | 9,743 | 9,471 |
| Frozen | 8,414 | 11,757 | 15,920 | 18,211 |
| Live birth Rate (per ET) | ||||
| Fresh (IVF-ET) | 16.2 % | 15.0 % | 16.9 % | 16.1 % |
| Fresh (ICSI) | 13.7 % | 12.6 % | 14.1 % | 13.5 % |
| FER | 19.3 % | 20.3 % | 22.3 % | 22.4 % |
| Number of infant resulting from ART | ||||
| Fresh | 10,338 | 9,279 | 10,226 | 9,934 |
| Frozen | 9,257 | 12,425 | 16,454 | 19,011 |
| Total | 19,595 | 21,704 | 26,680 | 28,945 |
| All live birth in JAPAN | 1,089,818 | 1,091,156 | 1,070,035 | 1,071,304 |
| ART infant rate per national birth | 1.8 % | 2.0 % | 2.5 % | 2.7 % |
| Number and rate of multiple pregnancy (per intrauterine pregnancy) | ||||
| twin | 3,078(11.0 %) | 2,099(6.7 %) | 1,880(5.2 %) | 1,906(4.7 %) |
| triplet or more | 143(0.5 %) | 40(0.1 %) | 37(0.1 %) | 40(0.1 %) |
| total | 3,221(11.5 %) | 2,139(6.8 %) | 1,917(5.3 %) | 1,946(4.8 %) |
| Unknown outcome of pregnancy | 3,828(13.1 %) | 3,491(10.7 %) | 1,751(4.7 %) | 2,644(6.4 %) |
ART assisted reproductive technology, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, FER frozen embryo replacement
Othersa include gamate intrafallopian transfer and zygote intrafallopian transfer