Table II.

Half Maximal Inhibitory Concentrations (IC₅₀) of Irinotecan, SN-38, and SN-38-SBEβCD Against Ovarian Cancer Cell Lines, A2780 and 2008, After 48 and 72 h of Incubation (Mean ± SD, n = 3)

	48 h incubation	72 h incubation
	(IC50)	(IC50)
A2780 cells
Irinotecan	4.15 ± 0.109 μM	2.21 ± 0.22 μM
SN-38	76.07 ± 0.50 nM*	7.72 ± 0.50 nM*
SN-38-SBEβCD complex	21.42 ± 1.09 nM**	4.33 ± 0.26 nM**
2008 cells
Irinotecan	26.38 ± 0.844 μM	12.88 ± 0.34 μM
SN-38	140.27 ± 3.06 nM*	31.66 ± 0.79 nM*
SN-38-SBEβCD complex	133.30 ± 2.82 nM***	29.69 ± 1.02 nM***

^* p < 0.0001 in comparison to irinotecan, ^** p < 0.001 in comparison to SN-38, ^*** p < 0.05 in comparison to SN-38