Table I.
Ratio of Mixed Surfactants Used in the Formulations Prepared at Various HLB Values
| HLB | Surfactant mixing ratio (weight percent) | |||||||
|---|---|---|---|---|---|---|---|---|
| Tween® 20/Span® 20 | Tween® 20/Span® 80 | Tween® 80/Spa® 20 | Tween® 80/Span® 80 | Cremophor® EL/Span® 20 | Cremophor® EL/Span® 80 | Cremophor® RH40/Span® 20 | Cremophor® RH40/Span® 80 | |
| 8 | N/A | 29.8/70.2 | N/A | 34.6/65.4 | N/A | 42.5/57.5 | N/A | 34.6/65.4 |
| 8.5 | N/A | 33.9/66.1 | N/A | 39.3/60.7 | N/A | 48.3/51.7 | N/A | 39.3/60.9 |
| 8.6 | 0/100 | 34.7/65.3 | 0/100 | 40.2/59.8 | 0/100 | 49.4/50.6 | 0/100 | 40.2/59.8 |
| 9 | 4.9/95.1 | 37.9/62.1 | 6.3/93.2 | 43.9/56.1 | 9.1/90.9 | 54.0/46.0 | 6.3/93.7 | 43.9/56.1 |
| 9.5 | 11.2/88.9 | 41.9/58.1 | 14.1/85.9 | 48.6/51.4 | 20.5/79.5 | 59.8/40.2 | 14.1/85.9 | 48.6/51.4 |
| 10 | 17.3/82.7 | 46.0/54.0 | 21.9/78.1 | 53.3/46.7 | 31.8/68.2 | 65.5/34.5 | 21.9/78.1 | 53.3/46.7 |
| 10.5 | 23.5/76.5 | 50.0/50.0 | 29.7/70.3 | 57.9/42.1 | 43.2/56.8 | 71.3/28.7 | 29.7/70.3 | 57.9/42.1 |
| 11 | 29.6/70.4 | 54.0/46.0 | 37.5/62.5 | 62.6/37.4 | 54.5/45.5 | 77.0/23.0 | 37.5/62.5 | 62.5/37.4 |
| 11.5 | 35.8/64.2 | 58.1/41.9 | 45.3/54.7 | 67.3/32.7 | 65.9/34.1 | 82.8/17.2 | 45.3/54.7 | 67.3/32.7 |
| 12 | 42.0/58.0 | 62.1/37.9 | 53.1/46.9 | 72.0/28.0 | 77.3/22.7 | 88.5/11.5 | 53.1/46.9 | 72.0/28.0 |
| 12.5 | 48.1/51.9 | 66.1/33.9 | 60.9/39.1 | 76.6/23.4 | 88.6/11.4 | 94.3/5.7 | 60.9/39.1 | 76.6/23.4 |
| 13 | 54.3/45.7 | 70.2/29.8 | 68.8/31.3 | 81.3/18.7 | 100/0 | 100/0 | 68.8/31.2 | 81.3/18.7 |
| 13.5 | 60.5/39.5 | 74.2/25.8 | 76.6/23.4 | 86.0/14.0 | N/A | N/A | 76.6/23.4 | 86.0/14.0 |
| 14 | 66.7/33.3 | 78.2/21.8 | 84.4/15.6 | 90.7/9.3 | N/A | N/A | 84.4/15.6 | 90.7/9.3 |
| 14.5 | 72.8/27.2 | 82.3/17.7 | 92.2/7.8 | 95.3/4.7 | N/A | N/A | 92.2/7.8 | 95.3/4.7 |
| 15 | 79.0/21.0 | 86.3/13.7 | 100/0 | 100/0 | N/A | N/A | 100/0 | 100/0 |
N/A not applicable