Table II.
Solubility of Nifedipine in Various Vehicles (n = 3)
| Vehicle | Solubility of nifedipine (μg/mL) |
|---|---|
| Oils | |
| Almond oils | 1,322.6 ± 207.4 |
| Apricot oils | 1,209.6 ± 22.3 |
| Caster oils | 7,656.5 ± 2,003.2 |
| Coconut oils | 1,869.6 ± 206.3 |
| Imwitor® 742 | 11,828.4 ± 1,655.3 |
| Miglyol® 810 | 4,027.0 ± 258.2 |
| Miglyol® 812 | 3,867.8 ± 152.0 |
| Olive oils | 1,244.9 ± 208.8 |
| Sunflower oils | 1,511.7 ± 174.9 |
| Fatty acids | |
| Decanoic acid | 1,590.5 ± 166.3 |
| Hexanoic acid | 4,020.3 ± 247.0 |
| Octanoic acid | 2,579.3 ± 199.8 |
| Oleic acid | 452.8 ± 66.8 |
| Ricinoleic acid | 3,271.5 ± 309.4 |
| Surfactants | |
| Cremophor® EL (HLB, 12–14) | 61,270.3 ± 6,150.7 |
| Cremophor® RH40 (HLB, 14–16) | 67,214.5 ± 9,823.5 |
| Span® 20 (HLB, 8.6) | 3,073.3 ± 69.2 |
| Span® 80 (HLB, 4.3) | 2,822.1 ± 535.1 |
| Tween® 20 (HLB, 16.7) | 76,066.3 ± 22,768.9 |
| Tween® 80 (HLB, 15) | 66,988.4 ± 2,479.5 |
| Solvents | |
| Acetonitrile | 8,461.4 ± 433.2 |
| Ethanol | 25,038.4 ± 6,540.4 |
| Isopropanol | 20,458.0 ± 6,596.8 |
| Water | 5.8 ± 0.1 |