Table 4.

Rotavirus Vaccine Effectiveness Estimates Against Acute Gastroenteritis Hospitalization^a in US Commercially Insured Infants and Children 8–20 Months of Age, 2007–2010

Calendar Year by Effectiveness	Vaccinated With ≥1 Dose of RV5 or RV1, %	Vaccinated		Unvaccinated		Total (Vaccinated and Unvaccinated)		Vaccine Effectivenessb	95% CI
		No. of Events	Total No. of Children	No. of Events	Total No. of Children	No. of Events	Total No. of Children
Direct effectiveness
2007	51.3	142	68,378	271	64,928			22	3, 37
2008	65.9	413	175,765	317	90,882			40	30, 48
2009	80.3	512	249,838	300	61,136			56	49, 62
2010	85.9	398	254,232	109	41,888			41	27, 53
Indirect effectiveness
2007	51.3			271	64,928			−8	−24, 6
2008	65.9			317	90,882			24	15, 33
2009	80.3			300	61,136			9	−3, 19
2010	85.9			109	41,888			45	33, 54
Total effectiveness
2007	51.3	142	68,378					12	−5, 27
2008	65.9	413	175,765					48	43, 53
2009	80.3	512	249,838					59	54, 62
2010	85.9	398	254,232					65	62, 69
Overall effectiveness
2007	51.3					413	133,306	0	−13, 11
2008	65.9					730	266,647	40	35, 45
2009	80.3					812	310,974	48	44, 52
2010	85.9					507	296,120	62	58, 66

Abbreviations: CI, confidence interval; RV1, monovalent rotavirus vaccine; RV5, pentavalent rotavirus vaccine.

^a During the prevaccine period (2001–2005), there were 2,021 events among 277,893 children.

^b Adjusted for birth month and age using the formula, (1 – hazard ratio) × 100.