Table 3.
Sequence Variants From Subjects With Prior Antiviral Treatment
| Sequence Varianta | Subjectsb | Specimensb | Study Dayc | Resequencing Resultd |
|---|---|---|---|---|
| (P468S), (E882K) | 2 | 2 | 0 | |
| P206S, P342L, T437M, G451S, S612N, (A636T), (A636V), (F638S), V654G, H686T. H886insA, T691S, P747L, K853E, G878E, A885M, (S893L), R900W, (R917H), V998I, L999I | 1 | 1 | 0 | |
| (A692G), (F718S), (Q795P) | 1 | 1 | 0 | Not found |
| A505V, G657D, G659D, (G687S), P859A, D879G, (S880L) | 1 | 2 | 0 | |
| D515E, A543S | 1 | 2 | 0 | Confirmed |
| S675G | 1 | 4 | 0 | |
| (Q229K), (E235G), (D247N), (D262N), (T271A), (D279N), (V284E), (D289N)e, (Y380C), (F396L), (L424V), (F460L), (R581H), (G667N), (I726T), (E793V), (G841S), (K947E) | 1 | 1 | 21 | Not found |
| (V373G), (S660G), (V902G), (M959T), E1010V | 1 | 1 | 21 | |
| (V476G), (V482G) | 1 | 1 | 21 | Inconclusivef |
| Q578L, Q795R | 1 | 1 | 49 | Not found |
| (S664G) | 1 | 1 | 49 | |
| K316E | 1 | 2 | Past end |
a Variants in parentheses were detected only as mixtures with wild type. Variants in italics are at conserved residues. Variants in bold were selected for phenotyping.
b Number of subjects or specimens per listed variant.
c Earliest study day of detection of variant. Past end = post treatment.
d Results of re-extraction and resequencing of the involved specimen. No resequencing where results not shown.
e Originally reported as D288N and phenotyped as such (Table 4).
f V476G and V482G were originally detected in the same specimen. Resequencing with optimally positioned primer showed wild type at both codons; 1 of 2 other primers showed a variant-wild type mix at both codons.