. 2013 Nov 23;209(8):1219–1226. doi: 10.1093/infdis/jit654

Table 5.

Genotypes and Phenotypes of Recombinant Viruses (Quebec)

UL54 Variant^a	Cidofovir		Ganciclovir		Foscarnet
UL54 Variant^a	EC50^b	Ratio^c	EC50^b	Ratio^c	EC50^b	Ratio^c
Control strain
wt	1.00		1.60		112
Newly phenotyped variants (N = 3)
N345S	0.67	0.7	1.94	1.2	99	0.9
V476G	0.80	0.8	1.50	0.9	50	0.4
Q578L	0.84	0.8	3.00	1.9	332	3.0

Bold: Results associated with decreased drug susceptibility.

Abbreviations: BAC, bacterial artificial chromosome; EC50, concentration required to reduce activity of the secreted alkaline phosphatase reporter by 50%; wt, wild type.

^a Mutation introduced into BAC and recombinant virus.

^b Drug concentration (µM) required to reduce plaque formation by 50%.

^c Ratio of EC50 to baseline strain.