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. 2014 Mar 12;25(4):877–883. doi: 10.1093/annonc/mdu014

Figure 2.

Figure 2.

(A) MRE11A isoform 1 and isoform 2 alternative splicing and the relative position of common SNP rs1805363 with sequencing forward (F) and reverse (R) primer relative positions indicated. (B) MRE11A isoform expression in bladder cancer cell lines and primary bladder tumours with different genotypes for rs1805363: (i) gel electrophoresis bands for MRE11A isoforms 1 and 2, GAPDH PCR amplified from cDNA from six bladder cancer cell lines (all wild-type GG genotype for rs1805363), primary bladder tumours A and B (heterozygote GA genotype for rs1805363) and primary bladder tumour C (homozygote variant AA genotype for rs1805363) and (ii) percentage expression of MRE11A for each isoform relative to overall MRE11A expression for each sample.