Table II.

Results of the GWIS on childhood tobacco smoke exposure and childhood-onset asthma

Ch	SNP	Closest gene∗	Type	Discovery			Replication
				N†	ORint‡	Pf	N†	ORint‡	Pf
1	rs2026604	S100A7L2	Downstream	3048	1.44	7.49 × 10−5	1003	0.83	.17
2	rs10184453	—	Intergenic	3048	1.53	8.85 × 10−5	1003	1.18	.30
2	rs895565	—	Intergenic	3048	1.53	7.26 × 10−5	1003	1.18	.30
2	rs11126185	—	Intergenic	3048	0.67	6.81 × 10−6	868	1.22	.16
3	rs4234677	CTD-2230D16.1	Within noncoding gene	3048	0.65	6.57 × 10−5	261	1.58	.22
3	rs264096	MAGI1	Intronic	3048	0.62	6.93 × 10−6	396	0.89	.63
3	rs17239426	KCNAB1	Intronic	3048	0.58	7.28 × 10−5	1003	1.18	.39
4	rs1425551	IRF2	Intronic	3048	1.40	6.92 × 10−5	1003	0.98	.86
5	rs162036	MTRR	Nonsynonymous	3048	0.60	8.26 × 10−5	1003	1.14	.45
5	rs7719963	—	Intergenic	3048	0.56	3.06 × 10−5	868	0.89	.59
5	rs7447231	—	Intergenic	3048	1.55	8.36 × 10−6	868	0.85	.31
5	rs10155635	—	Intergenic	3048	1.56	7.55 × 10−6	261	0.62	.11
5	rs10038850	—	Intergenic	3048	1.53	1.51 × 10−5	261	0.41	.04
5	rs10479335	—	Intergenic	3048	1.52	5.98 × 10−5	868	0.85	.29
5	rs2312164	—	Intergenic	3048	1.42	7.18 × 10−5	1003	0.82	.14
5	rs13357477	—	Intergenic	3048	1.58	3.59 × 10−6	868	0.83	.24
5	rs12719549	—	Intergenic	3048	1.57	4.61 × 10−6	868	0.82	.21
5	rs4607330	—	Intergenic	3048	1.59	2.70 × 10−6	868	0.85	.31
6	rs441463	LYRM4	Intronic	3048	1.41	4.91 × 10−5	1003	0.90	.42
6	rs1575472	PACRG	Intronic	3048	1.78	1.37 × 10−5	1003	1.51	.06
7	rs17544971	GRB10	Intronic	3048	1.70	8.12 × 10−5	868	1.26	.28
9	rs4977750	MTAP	Nonsense-mediated decay transcript	3048	0.61	1.91 × 10−5	1003	0.93	.66
13	rs4769148	—	Intergenic	2445	0.67	4.45 × 10−5	261	0.72	.21
13	rs12874184	—	Intergenic	3048	1.98	8.75 × 10−5	868	1.18	.50
13	rs16972472	—	Intergenic	3048	1.79	9.59 × 10−5	868	0.79	.32
14	rs10141836	OR11G2	Upstream	3048	0.70	8.89 × 10−5	1003	0.90	.41
15	rs2602923	C15orf41	Intronic	3048	1.61	4.52 × 10−5	1003	1.19	.33
16	rs13331814	ZP2	Intronic	3048	0.62	8.38 × 10−5	868	0.85	.34
19	rs11085080	PLIN5	Intronic	3048	0.51	6.30 × 10−5	1003	1.12	.63
20	rs6077755	PSMF1	Upstream	3048	1.52	6.65 × 10−6	1003	1.11	.47
X	rs6641609	PRKX	Intronic	1939	0.49	3.43 × 10−5	261	1.90	.15

Ch, Chromosome; OR_int, odds ratio interaction; Pf, P value, fixed effect.

^∗Closest gene within range of 500 kb of the position of the SNP.

^†Number of cases and control subjects included in the meta-analysis.

^‡Additive genetic model.