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. Author manuscript; available in PMC: 2014 Mar 29.
Published in final edited form as: Steroids. 2008 Dec 24;74(7):568–572. doi: 10.1016/j.steroids.2008.12.004

Fig. 4.

Fig. 4

Model of PR-scaffolding interactions. Previously reported interactions between PR (PxxP, proline-rich domain) and/or ER (phospho-tyrosine 537) and c-Src (SH3 domain with PR, SH2 domain with ER), as well as interactions between PR (ERID, estrogen receptor interaction domain) and ER (LBD, ligand-binding domain) have been shown to be necessary for progesterone-induced c-Src/MAPK activation [23–25,36,37]. Additionally, complex formation between PR (CD domain) and MEK1 (D domain) may be necessary for MEK1 docking and subsequent PR posttranslational modification and activation.