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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Int J Neuropsychopharmacol. 2014 Jan 15;17(5):765–777. doi: 10.1017/S146114571300165X

Table 1.

Effects of inhibition of signaling pathways and that of interacting receptors on the DPN-increased T80 value

Vehicle +
vehicle		 Vehicle +
DPN		 PD98059 +
DPN		 K252a +
DPN		 JB-1+

DPN
T80
% change		 106.0
±5.04		 149.5*
±9.61		 103.1#
±6.00		 96.7#
±6.05		 103.1#
±7.02
a

Mean of T80 value expressed as a percentage of pretreatment value ±SEM of 5-7 rats

Two way analysis of variance was carried out for the percent change in T80 values for DPN and/or the inhibitors. Inhibitors alone, not shown in this table did not change T80 values (as shown in Figures 2a and 4a). The data from the inhibitors alone were included in the statistical analyses. There was a significant main effect for inhibitor [F(3,41)=14.122, p<0.001] and for DPN [F(1,41)=7.522, p=0.009], as well as a significant interaction between inhibitor x DPN [F(3,41)=12.984, p<0.001]. Dunnett’s post hoc analysis was carried out.

*

p < .001, comparing DPN within PBS and

#

p < .001, comparing value of DPN with inhibitor to value of DPN alone.