Table 3.
Postmenstrual and chronological age of onset1 [with 95% confidence intervals (CI2)] of any stage ROP3 (among infants with ROP age of onset determined)
| Cumulative Percent with Onset of ROP (by age of onset and ROP category) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ROP type | n | Min4 | 1% | 5% | 25% | 50% | 75% | 95% | 99% | Max4 |
| Postmenstrual Age (weeks) | ||||||||||
| Any ROP (95%CI) | 634 | 29.3 | 30.4 (29.6-30.7) | 31.4 (31.1-31.4) | 32.7 (32.4-32.9) | 33.9 (33.7-34.0) | 35.1 (34.9-35.4) | 38.0 (37.3-38.7) | 41.0 (39.9-43.6) | 46.7 |
| Type 2 ROP5 (95%CI) | 158 | 29.3 | 29.7 (29.3-30.7) | 31.1 (30.6-31.7) | 34.3 (33.6-34.9) | 36.1 (35.7-36.9) | 38.1 (37.6-38.7) | 40.4 (39.9-43.7) | 46.4 (43.3-46.9) | 46.9 |
| Severe (Type 1/treated) ROP (95% CI) | 128 | 32.1 | 32.7 (32.1-32.7) | 33.9 (32.7-34.3) | 35.1 (34.7-35.4) | 36.4 (35.7-36.9) | 38.6 (37.4-40.0) | 43.3 (41.0-45.0) | 45.0 (44.4-53.1) | 53.1 |
| Cumulative Percent with Onset of ROP (by age of onset and ROP category) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ROP type | n | Min | 1% | 5% | 25% | 50% | 75% | 95% | 99% | Max |
| Chronological Age (weeks) | ||||||||||
| Any ROP (95%CI) | 634 | 4.0 | 4.6 (4.1-4.7) | 5.4 (5.0-5.6) | 6.9 (6.6-6.9) | 8.0 (7.9-8.1) | 9.4 (9.1-9.6) | 11.9 (11.3-13.0) | 15.3 (14.4-18.0) | 19.7 |
| Type 2 ROP3 (95%CI) | 158 | 4.4 | 4.6 (4.4-5.6) | 6.3 (4.7-6.6) | 8.7 (7.9-9.6) | 10.8 (10.3-11.4) | 12.6 (12.0-13.1) | 15.0 (14.1-19.6) | 21.0 (17.0-22.7) | 22.7 |
| Severe (Type 1/treated) ROP (95% CI) | 128 | 6.4 | 7.1 (6.4-7.9) | 8.4 (7.1-8.9) | 9.8 (9.3-10.3) | 11.3 (10.6-11.7) | 13.1 (12.4-14.4) | 17.0 (16.1-19.0) | 19.0 (18.9-28.4) | 28.4 |
1
Age of onset is defined as the age at which the specified type of ROP was first observed while following the study monitoring protocol. For “Any ROP”, this is the first exam with any stage of ROP in any zone.
2
Confidence interval
3
Retinopathy of prematurity
4
Min = minimum age at which designated severity of ROP was identified; max = maximum age.
5
Type 2 ROP is defined as stage 3 in zone II, no plus disease or stage 1 or 2 in zone I, no plus disease. (85 of these infants had ROP that regressed and 73 infants later developed severe ROP.)