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Organ distribution of liposomes (200 and 600 nm) and PEG-DSPE micelles in mice 1, 3 and 24 h after their intravenous or inhalation administration. All nanocarriers were labeled with near-infrared fluorescent Cy5.5 dye; total fluorescence in organs was measured using the IVIS Xenogen optical imaging system, and normalized per entire organ weight. A, Intravenous delivery; B, Inhalation delivery. Means ± SD are shown.
