Table 1.

Disparate expression of miRNAs between rBM 3-D and 2-D cultures of mK-ras-LE cells. Total cell RNA was extracted from rBM 3-D and 2-D cultures. miRNA arrays were carried out and analyzed as described in Methods. A fold change of each miRNA was obtained by setting the values from 2-D culture to one. The results were average of three miRNA microarrays. The miRNAs bearing documented tumor-modulating properties were highlighted in bold.

rBM 3-D/2-D
Lower Expression		Higher Expression
Gene Name	Fold Change	Gene Name	Fold Change
mmu-miR-689	0.03	mmu-miR-1937b	2.06
mmu-miR-19b	0.09	mmu-miR-99b	2.17
mmu-miR-106a	0.09	mmu-miR-2142	2.22
mmu-miR-29b	0.11	mmu-miR-466f-3p	2.25
mmu-miR-20a	0.19	mmu-miR-200a	2.33
mmu-miR-18a	0.23	mmu-miR-2133	2.39
mmu-miR-106b	0.24	mmu-miR-23b	2.47
mmu-miR-350	0.26	mmu-miR-574-5p	2.61
mmu-miR-29c	0.26	mmu-miR-122	2.72
mmu-miR-155	0.27	mmu-miR-2137	2.75
mmu-miR-17	0.30	mmu-miR-2138	3.06
mmu-miR-29a	0.34	mmu-miR-192	3.15
mmu-miR-31*	0.41	mmu-miR-2134	3.23
mmu-miR-21	0.42	mmu-miR-195	3.35
mmu-miR-92b	0.42	mmu-miR-191	3.40
mmu-miR-290-5p	0.46	mmu-miR-2132	3.47
mmu-let-7f	0.47	mmu-miR-467f	3.71
		mmu-miR-466i	4.01
		mmu-miR-200b	4.20
		mmu-miR-1187	6.02
		mmu-miR-429	6.31
		mmu-miR-214	7.15