Figure 1.

Figure 1A: Photomontage of axial T2-weighted MR image, overlaid MR spectral grid, and corresponding MR spectra array in a 62 year old with recently diagnosed Gleason 4+3 prostate cancer and a baseline serum prostate specific antigen level of 6.3 ng/mL. A large mass-like focus of reduced T2 signal intensity in the peripheral zone of the right mid-gland is associated with multiple voxels demonstrating high choline peaks (white arrows). This was considered a treatable tumor focus by both readers. The electronic contour generated by reader 1 is shown on the axial T2-weighted image.

Figure 1B: Photomontage of whole mount step section slide, with tumor focus outlined, and the corresponding axial image from Figure 1A. Selected pairs of matching points have been selected along the outline of the prostate on both histopathological and MR images in MATLAB.

Figure 1C: Photomontage of digitally extracted and matched tumor outlines on after deformable co-registration of histopathological and axial T2 images. The first image shows the histopathological tumor outline, the second image shows the MR tumor outline, and the final image shows the differences betlackween the two outlines (white indicates areas where the MR outline overestimated the tumor and white indicates areas where the MR outline underestimated the tumor).

Figure 1D: Photomontage illustrating quantification of contour differences between histopathological and MR contours.

Figure 1E: Quantification of differences in MRI and Path contours as a function of capsular and non-capsular borders.