Skip to main content
. Author manuscript; available in PMC: 2014 Mar 30.
Published in final edited form as: Cell. 2013 May 2;153(4):910–918. doi: 10.1016/j.cell.2013.04.025

Figure 4. Mutiplexed Genome Editing in ES Cells and Mouse.

Figure 4

(A) Multiple gene targeting in ES cells.

(B) One-step generation of mice with multiple mutations. Upper: multiple targeted mutations with random indels introduced through NHEJ. Lower: multiple predefined mutations introduced through HDR-mediated repair.