Skip to main content
. 2014 Apr;184(4):1104–1118. doi: 10.1016/j.ajpath.2013.12.015

Figure 1.

Figure 1

Glucose tolerance is impaired in guinea pigs with prediabetic IGT and type 2 diabetes (T2DM). Normal glucose tolerance in nondiabetic (non-DM) guinea pigs before initiating an HFHC diet by OGTT (A) and corresponding area under the curve (AUC) (B). Glucose tolerance was impaired in guinea pigs fed the HFHC diet alone, with reduced glucose disposal at 60 minutes of OGTT (C) and an overall increase in AUC (D) compared with the same guinea pigs before initiating the diet. A diabetic level of IGT in T2DM guinea pigs 11 weeks after combined HFHC/STZ diabetogenic treatment (E) with a marked increase in AUC (F). Data are given as means ± SD. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001, and ∗∗∗∗P ≤ 0.0001 compared with non-DM levels.