Table 1.
Metabolic Parameters from Non-DM, Glucose-Intolerant, and T2DM Guinea Pigs before Infection with M. tuberculosis (Day 0) and 30, 60, and 90 Days after Infection
| Parameter | Model | Day 0 | Day 30 | Day 60 | Day 90 |
|---|---|---|---|---|---|
| TG (mg/dL) | Non-DM | 34.7 ± 9.4 | 58.4 ± 16.3 | 40.59 ± 19.3 | ND |
| IGT | 93.1 ± 63.7∗ | 66.9 ± 44.1 | 77.1 ± 42.1 | ND | |
| T2DM | 101 ± 47∗ | 52.2 ± 13.9 | ND | ND | |
| FFA (mmol/L) | Non-DM | 132.3 ± 24.8 | 380 ± 46.2††† | 260.6 ± 8.6† | 252.7 ± 25.4† |
| IGT | 146.6 ± 47.5 | 406.1 ± 84††† | 256.9 ± 19.2† | 240.3 ± 16.6† | |
| T2DM | 172.6 ± 47.4∗ | 454.2 ± 90.7††† | ND | ND | |
| AGE (μg/mL) | Non-DM | 1.079 ± 0.181 | 1.266 ± 0.188 | 1.125 ± 0.179 | 0.956 ± 0.122 |
| IGT | 0.973 ± 0.011 | 1.186 ± 0.273 | 1.007 ± 0.094 | 0.987 ± 0.14 | |
| T2DM | 1.163 ± 0.168 | 2.522 ± 0.532†† | ND | ND |
Data are given as means ± SD.
ND, not determined; non-DM, nondiabetic; T2DM, diabetic; TG, triglyceride.
∗
P ≤ 0.05 compared with non-DM levels.
†
P ≤ 0.05, ††P ≤ 0.001, and †††P ≤ 0.0001 compared with preinfection levels.