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Evidence for ovarian hormone regulation of COX-2 in rat mammary epithelium. A: Representative IHC staining (brown signal) and quantification (right) of COX-2 expression in rat mammary tissue across the estrous cycle. P = 0.38, one-way analysis of variance. B: COX-2 IHC staining and quantification in rat mammary tissue after estradiol (E) or estradiol + progesterone (E + P) treatment. Veh, vehicle. ∗P < 0.05; ∗∗P < 0.01, one-tailed unpaired t-test.
