Table 3.

Biological pathways overrepresented (p < 0.05) in the SNP-rich dataset, which includes transcripts with at least six SNPs in their 500-bp upstream regions.

KEGG pathway	Number of genes from the SNP-rich dataset belonging to the pathway	Fold enrichment	p-Value	Genes
Olfactory transduction (Pathway_ID—hsa04740)	45	1.68	6.37E-04	OR10A5, OR52H1, OR51B2, OR1L8, OR1A2, OR5D16, OR52J3, OR51F1, OR1N2, OR8S1, OR1L3, OR11G2, OR13C5, OR4C16, OR10G9, OR8I2, OR51L1, OR7C2, OR2C3, OR8G1, OR14C36, OR2AG1, OR2B11, OR8G5, OR11L1, OR4M2, OR6C74, OR9G1, OR6C75, OR6T1, OR2W3, OR51G2, OR10Z1, OR12D2, OR10AD1, OR52E6, OR11H6, OR4A15, OR4C45, OR10Q1, OR5H6, OR7D4, OR6K6, GNAL, PDE1C
Antigen processing and presentation (Pathway_ID—hsa04612)	24	4.0	2.11E-08	HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-DQA2, HLA-G, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DRA, HSP90AB1, IFNA21, KLRC3, IFNA10, KIR2DS4, HSPA2, TAP2, TAP1, HSPA6, IFNA16, IFNA17, CD4