Figure 1.

MRI from a patient with MCI with boundaries of the three areas needed for calculating the Medial Temporal Atrophy index (MTAi). The section passes through the interpeduncular fosae. The three areas are: (1) the medial temporal lobe region (A), defined in a coronal brain slide as the space bordered in its inferior side by the tentorium cerebelli, in its medial side by the cerebral peduncles, in its upper side by the roof of the temporal horn of the lateral ventricle and in its lateral side by the colateral sulcus and a straight-line linking the colateral sulcus with the lateral edge of the temporal horn of the lateral ventricle; (2) the parenchima within the medial temporal region, that includes the hippocampus and the parahippocampal girus (B); and (3) the body of the ipsilateral lateral ventricle (C).