Table 4. Number of significant genes observed to overlap in schizophrenia (SZ) and bipolar (BD) datasets.
Smallest p-value per gene | Product of p truncation ≤ 0.01 | Product of p truncation ≤ 0.001 | |||||||
---|---|---|---|---|---|---|---|---|---|
α=0.05 | α=0.01 | α=0.001 | α=0.05 | α=0.01 | α=0.001 | α=0.05 | α=0.01 | α=0.001 | |
SZ | 703 | 175 | 41 | 425 | 140 | 39 | 98 | 75 | 30 |
BD | 790 | 197 | 41 | 445 | 159 | 30 | 94 | 63 | 24 |
Overlap | 85 | 14 | 1 | 37 | 11 | 2 | 5 | 2 | 0 |
Number of overlapping genes (1000 permutations with shared controls) | |||||||||
Median | 60 | 5 | 0 | 33 | 4 | 0 | 2 | 1 | 0 |
Min | 27 | 0 | 0 | 12 | 0 | 0 | 0 | 0 | 0 |
Max | 93 | 16 | 5 | 60 | 18 | 5 | 8 | 7 | 3 |
empirical p-value * | 0.014 | 0.007 | 0.402 | 0.305 | 0.017 | 0.09 | 0.063 | 0.415 | NA |
comparing overlap on observed and simulated data