Scheme 3.
Reagents and conditions: (a) CDI, THF, then hydrazine-hydrate, 23 °C; (b) (1) 1-aza-2-methoxy-1-cycloheptene, PhCl, MW, 180 °C; (2) PhI, Cs2CO3, Cu2O, L, NMP-PEG, 100 °C.
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