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Reagents and conditions: (a) o-toluidine, NMP, 60 °C; (b) hydrazine, Ra-Ni, MeOH, 23 °C; (EtO)3CH, TsOH, THF, MW, 120 °C; (d) R1R2NH or R3NH2, HATU, DIPEA, DMF, 23 °C; (e) (COCl)2, DMF, DCM, 23 °C, then piperidine-HCl, DCM, 23 °C; (f) R3NH2, DIPEA, NMP, 120 °C.
