Table 2.

SAR of ML148 and related analogues.

Compound	R1	IC50 (nM)a	Compound	R2	IC50 (nM)a
ML148		19	14a	phenyl	22
11a		22	14b	2-OMe-phenyl	27
11b		271	14c	3-Cl-phenyl	12
11c		48	14d	3-OMe-phenyl	19
11d		68	14e	3-CF3-phenyl	48
11e		68	14f	3-iPr-phenyl	68
11f		76	14g	3-tBu-phenyl	171
11g		1524	14h	4-Me-phenyl	19
11h		383	14i	4-Cl-phenyl	22
11i		383	14j	4-OMe-phenyl	19
11j		429	14k	4-CF3-phenyl	86
11k		961	14l	4-tBu-phenyl	54
11l		1358	14m	tBu	34
11m		2710	14n	nBu	68
11n		3040

^adetermined using the HTS enzymatic assay and tested in triplicate.