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. 2014 Mar 10;6(3):1091–1111. doi: 10.3390/v6031091

Figure 7.

Figure 7

Model binding of multivalent virus (V) to bivalent (DAF)2-Fc on beads occurs in two steps (S, M, L refer to small, medium, and large RNA segments of the viral genome) [47]. First, virus particles in solution at concentration [V], each present an estimated 562 Gn-Gc spikes that, with equal probability, can bind to free bead-borne (DAF)2-Fc sites with constants, kon and koff. Second, once singly bound, the virus-DAF complex [VD1] can form [VD2] by binding to the second DAF with rate constants kx and k−x.