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Pre-exposure prophylaxis with DEF201 protects hamsters from lethal s.c. RVFV challenge. Hamsters in each experimental group (n = 10) were treated i.n. with 108 PFU of DEF201 or empty vector (EV) on (A) day −1, (B) day −7, (C) day −14, or (D) day −21 relative to the time of infection with 30 PFU of RVFV. Kaplan-Meier survival curves are shown. **p < 0.01, ***p < 0.001 compared to respective EV controls.
