Figure 4.
HRT-RCM highly reflective small cells stained positively for Ly-6G, a PMN marker. (a) HRT image of infiltrating highly reflective bodies (light spots) 8 hours after epithelial injury. Immediately after HRT imaging the eye was removed and labeled with a primary antibody against Ly-6G conjugated with FITC. (b) Fluorescence microscopy of the same corneal region as (a). Comparison of the two images confirms the identity of the cells imaged with HRT-RCM to be Ly-6G+ PMNs. There is a very slight shift in cell positions due to the whole-mount process but out of 51 cells identified in (a), only one could not be correspondingly identified in (b).