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Metabolism of propofol. Less than 1% of propofol is excreted unchanged in the urine. Forty percent of propofol is rapidly conjugated by the liver to glucuronide (Glu) and excreted by the kidneys. Alternatively, 60% of propofol is hydroxylated (OH), subsequently conjugated to glucuronide (Glu) or sulfate (OSO3), and then excreted in the urine.
