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. Author manuscript; available in PMC: 2015 Jan 13.
Published in final edited form as: Cancer Cell. 2014 Jan 13;25(1):12–19. doi: 10.1016/j.ccr.2013.12.005

Figure 2. Sirtuins Are Central to Metabolic Reprogramming during Aging and Cancer.

Figure 2

Sirtuins control key nodes in the regulation of glycolysis (HIF-1α, HIF-2α, and c-Myc) and oxidative phosphorylation (PGC-1α, LKB1, and TCA enzymes). A decline in the activity of the sirtuin family of enzymes in old age is hypothesized to lead to a shift toward a predominantly glycolytic, Warburg-like metabolism that could contribute to the exponential increase in cancer susceptibility during aging.