Table 1.

Characteristics of the studies included in the review

Study	Parameters assessed	Intervention	First dose timing*	Species	Model of ischemia
Arumugam et al., 2010	lesion volume, neurological score	calorie restriction	−3m	C57 mouse	MCAO
Bobyn et al., 2005	open field, neuronal viability	calorie restriction	−28d	gerbil	2VO
Go et al., 1988	survival, edema	calorie restriction	−4d	rat	global
Gueldry et al., 1990	edema	ketone administration	−0.5h	SD rat	microspheres
Massieu et al., 2003	lesion volume	ketone administration	−14d, −7d, 0h	Wistar rat	iodoacetate
McEwen and Paterson, 2010	open field, neuronal count	calorie restriction	+1h	Gerbil	2VO
Puchowicz et al., 2008	lesion volume, edema	ketogenic diet	−21d	Wistar rat	MCAO
Roberge et al., 2008a	radial maze, neuronal count	calorie restriction	−3m	Wistar rat	4VO
Roberge et al., 2008b	elevated maze, open field, neuronal count	calorie restriction	−3m	Wistar rat	4VO
Robertson et al., 1992	lesion volume	calorie restriction, ketone administration	−12h	LE rat	2VO
Suzuki et al., 2001	survival, edema	ketone administration	−0.5h	ddY mouse	global
Suzuki et al., 2002	lesion volume, edema	ketone administration	+0.5h	Wistar rat	MCAO
Tai et al., 2008	neuronal count	ketogenic diet	−25d	SD rat	4VO
Xu et al., 2010	NOR	ketogenic diet	−21d	F344 rat	hypoxia
Yoon et al., 2011	lesion volume	calorie restriction	−3m	C57 mouse	MCAO
Yu and Mattson, 1999	lesion volume, neurological score	calorie restriction	−3m	SD rat	MCAO

^*First dose timing in relation to onset of experimental stroke.

MCAO = middle cerebral artery occlusion; m = months; d = days; h = hours; VO = vessel occlusion; SD = Sprague-Dawley rat; LE = Long Evans rat; NOR = novel object recognition.