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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Neurosci. 2013 Dec 22;17(2):215–222. doi: 10.1038/nn.3607

Figure 2. Conserved CpH methylation in orthogolous regions of the human brain DNA.

Figure 2

(a) Sanger bisulfite sequencing results of orthologous regions in the adult human brain and spleen genomic DNA. (b) Consistent levels of CpH methylation in multiple adult human cortical genomic DNA samples (Ctx1–3). (c) Reduced representation bisulfite sequencing (RRBS) data generated by the ENCODE project30 were analyzed using the mitochondrial CpH methylation rate (~1%) as the background probability. Percentage of mCpG/mCpH was corrected by the FDR estimated by a binomial distribution. (d) Quantification of numbers of mCpHs for each of the 15,417 one-to-one orthologous gene pairs between mouse and human (Ensembl annotations). A gene was considered CpH-methylated if two or more CpHs were ≥25% methylated (P value is indicated, χ2 test)