4% Lovaza® decreases LPS induced cytokines in cultured splenocytes from (NZB×NZW)F1 female mice. Two-month-old mice were fed semi-purified diets containing 1% placebo, 4% placebo, 1% Lovaza®, 4% Lovaza®, 4% FO-18/12 and standard LC diet as a control. At eight months of age, splenocytes were isolated, cultured aseptically and stimulated with LPS for 24 h. 4% Lovaza® fed mice showed significantly decreased (A)IL-1β, (B)IL-6, (C) TNF-α and (D) TGF-β in conditioned medium of splenocyte culture by ELISA (5 mice/group). Results are expressed as mean±SEM. *P < 0.05 versus LC and placebo controls, ≠P < 0.05 versus placebo by ANOVA