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. Author manuscript; available in PMC: 2015 Mar 4.
Published in final edited form as: Cell Metab. 2014 Feb 20;19(3):470–483. doi: 10.1016/j.cmet.2014.01.012

Figure 4. Enhanced glycolysis boosts proliferation of Myc super-competitors.

Figure 4

A. cCM, but not ncCM, generated from co-cultures depleted of p53 (but not control dsRNA) prevents accelerated proliferation of naïve Myc cells. Values in A and B are the mean of 5 independent experiments; cells in co-cultures and naïve cells were treated with p53 or control dsRNA in this figure. Error bars in this figure are SD.

B. Naïve WT cells treated with cCM from p53-deficient co-cultures proliferate faster than cells treated with cCM from co-cultures with control dsRNA, and faster than ncCM-treated cells.

C. Growth curve of Myc cells grown in cCM and ncCM from cyt-c-d or glut1-depleted co-cultures. Values are mean of 2 independent experiments.

D. Growth curve of WT cells grown in cCM and ncCM from cyt-c-d or glut1-depleted co-cultures. Values are mean of 2 independent experiments.