Table 2.

Several clinical examples of combined sepsis biomarkers

^ap (sepsis) = e^{(-28.6106 + 0.8912 × ln(PCT) + 4.3571 ×ln(C3a)}/[1 + e^{(-28.6106 + 0.8912 × ln(PCT) + 4.3571 × ln(C3a)}].

^b"bioscore" was calculated by scoring as 0 or 1 values below or above each threshold value for sTREM, PCT, and CD64 index.

^cSepsis Score = probability of severe sepsis = [e^{(raw score)}/1 + e^{(raw score)}] × 100; Raw Score = -8.7 + 0.63 (NGAL quartile) + 0.41 (IL-1ra quartile) + 0.50 (protein C quartile) APACHE-II, acute physiology and chronic health evaluation II; AUC-ROC, areas under receiver operating characteristic curves; BP, blood pressure; CD, cluster of differentiation; CRP, C-reactive protein; C3a, complement 3a; HR, heart rate; IL-1ra, interleukin-1 receptor antagonist; MCP, monocyte chemoattractant protein; MIF, macrophage migration inhibitory factor; NGAL, neutrophil gelatinase-associated lipocalin; PCT, procalcitonin; sTREM-1, soluble triggering receptor expressed on myeloid cell-1, suPAR; soluble form of urokinase-type plasminogen activator receptor, WBC; white blood cell.