TABLE 6.
Effect of maternal iron supplementation on offspring blood pressure and kidney function at 4.5 y in Bangladesh1
| n | Model 12 | P value R2 (%) | n | Model 23 | P value R2 (%) | n | Model 34 | P value R2 (%) | |
| Systolic pressure (mm Hg) | 2312 | −0.04 (−0.80, 0.72) | 0.91 (−0.04) | 2196 | 0.06 (−0.71, 0.84) | 0.87 (−0.04) | 1969 | 0.04 (−0.76, 0.84) | 0.93 (−0.05) |
| Diastolic pressure (mm Hg) | 2312 | 0.26 (−0.39, 0.90) | 0.44 (−0.02) | 2196 | 0.33 (−0.33, 1.00) | 0.33 (0.00) | 1969 | 0.42 (−0.27, 1.11) | 0.23 (0.02) |
| Kidney volume (cm3/m2) | 1068 | −0.10 (−2.40, 2.21) | 0.93 (−0.09) | 968 | −0.54 (−2.88, 1.80) | 0.65 (−0.08) | 861 | −0.91 (−3.38, 1.57) | 0.47 (−0.05) |
| GFR5 [mL/(min · 1.73 m2)] | 1224 | 4.47 (−0.32, 9.26) | 0.07 (0.19) | 1222 | 5.05 (0.36, 9.74) | 0.04 (0.27) | 1093 | 4.68 (−0.22, 9.58) | 0.06 (0.22) |
Values are regression coefficients (β) showing the difference in mean blood pressure and kidney function (95% CI) for individuals born to women in the Fe60F compared to Fe30F intervention group, derived from linear regression analysis. R2 refers to adjusted partial R2 for all models. Fe60F, 60 mg of iron and 400 µg of folate; GFR, glomerular filtration rate; MMS, multiple micronutrient supplement.
Model 1, adjusted for the MMS intervention dummy and food intervention variables only.
Model 2, additionally adjusted for age, sex, wealth index, tertiles of maternal blood pressure (blood pressure models only), and season of birth.
Model 3, as model 2 but additionally adjusted for height, BMI, fat-free mass, diarrhea in past 2 wk, and feeling well on the study day.
GFR calculated from plasma cystatin C (17).