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Sirtuin histone substrates
| Sirtuin | Histone substrate | Biological relevance |
|---|---|---|
| SIRT1 | H3K9 H3K14 H3K56 H4K16 H1K26 |
Chromatin organization, DNA repair/genome stability, cancer |
| SIRT2 | H4K16 H3K56 |
Chromatin condensation/mitosis, DNA repair, cancer |
| SIRT3 | H4K16 | Chromatin silencing, DNA repair, cellular stress |
| SIRT4 | None | |
| SIRT5 | None | |
| SIRT6 | H3K9 H3K56 |
Telomeric chromatin/senescence, DNA repair/genome stability |
| SIRT7 | H3K18 | Cellular transformation |
