Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Nat Chem. 2013 Sep 29;5(12):1000–1005. doi: 10.1038/nchem.1764

Figure 3.

Figure 3

High-level description and molecular detail of the ‘positive edge’ circuit. (a) An incoherent feed-forward loop with inversed logic. (b) Detailed mechanism of the incoherent feed forward loop. Here D is ablated and E is activated by the input signal. Active, inactive, caged and ablated molecules are shown in white, gray, yellow and purple, respectively. (c) Mechanisms of the photo-ablation of Dlabile. (d) Mechanisms of the photo-activation of E1caged. Domains 11, 13, 15, and 16 are 8-nt long; domain 12 is 11-nt long; domain 14 is 15-nt long; domains 21 and 22 are 20-nt long. See Supplementary Table S1 and Supplementary Figure S8b for sequences.