Panels A-C: Mean blood glucose (mg/dL) (± S.E.M.) over time for control and SOD1-G93A mice at the early, middle, and late stages. Male and female mice were combined within groups. Systemic glucose clearance in early, middle, and late stage SOD1-G93A mice did not differ significantly from that of control mice. Panel D: Mean serum insulin (ng/mL) (± S.E.M.) for control and SOD1-G93A mice at the early, middle, and late stages. At each stage, 2-sample t-tests revealed no significant differences in mean serum insulin between control and SOD1-G93A mice. Breaks indicate that across-stage comparisons were not performed.