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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Neuropharmacology. 2013 Dec 25;79:420–431. doi: 10.1016/j.neuropharm.2013.12.017

Table 2.

Analysis of Variance (ANOVA) for Various Data Sets

Experiment Measurement Challenge Means Compared F-statistic p value
Figure 2 Ioxidation/Icontrol a 100 μM ACh H2O2 alone, H2O2+ACh, H2O2+Mor, H2O2+ACh+Mor 3.66 0.024
“ Ioxidation/Icontrol 100 μM ACh + 10 μM Mor H2O2 alone, H2O2+ACh, H2O2+Mor, H2O2+ACh+Mor 0.42 0.737
Figure 3 Itreatment/Icontrol b 100 μM ACh, 100 μM ACh + 10 μM Mor DTT, H2O2+ACh+Mor 18.2 9.13 × 10−5
Figure 4 Itime point/Icontrol 100 μM ACh + 10 μM Mor All 13 post-treatment c time points 4.05 0.000102
Figure 5 IMTS/Ipost-treatment d 5 μM ACh Control, H2O2+ACh+Mor, H2O2 alone, H2O2+ACh+Mor*, DTT 40.5 2.67 × 10−16
“ IMTS/Ipost-treatment 5 μM ACh + 10 μM Mor Control, H2O2+ACh+Mor, H2O2 alone, H2O2+ACh+Mor*, DTT 2.30 0.069
Figure 6 Ioxidation/Icontrol ACh H2O2+ACh+Mor and H2O2 alone for 3 Double Cysteine Pairs e 4.18 0.00593
“ Ioxidation/Icontrol ACh + Mor H2O2+ACh+Mor and H2O2 alone for 3 Double Cysteine Pairs 4.25 0.00327
a

Four oxidation treatment conditions were as noted by Means Compared and in the Figure 2 legend.

b

The ratios IDTT/Icontrol and IH2O2/Icontrol for the two challenges listed were compared.

c

As described in the Figure 4 legend, these means were in groups from three experiments: post-oxidation, repeated challenge (100–500 sec); post-oxidation with washout (100, 400, 500 sec); 5-min ACh + Mor exposure, repeated challenge (100–500 sec).

d

The five treatments were as noted by Means Compared and in the Figure 5 legend.

e

Three double-cysteine mutants were α3L158CA179Cβ2, α3L158CG181Cβ2, α3L158CK183Cβ2.