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. 2014 Apr 1;127(7):1476–1486. doi: 10.1242/jcs.138495

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© 2014. Published by The Company of Biologists Ltd

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Fig. 3. — Depletion of sept7b causes defects in the structure of the pronephros. (A–E) Electron micrographs of control and sept7b-morphant kidneys at 4 dpf. (A) Wild-type podocytes show regular foot processes connected by slit diaphragms (arrows). Glomerular basement membrane, GBM. (B,C) Podocytes of a sept7b morphant (TBMO) show foot process effacement (arrowhead) and microvillar-type cell processes (m) on their apical surface. Occasional slit diaphragms (arrow) were observed. (D) A pronephric tubule of the wild-type larva (ctrl) shows regular microvilli (mv) and cilia (c) morphology. (E) A tubule in a sept7b morphant appears dilated and shows sparse and irregular microvilli and scattered cilia. (F,G) The cilia in both control (F) and TBMO morphants (G) show the normal 9+2 structure of microtubules. The outer dynein arms are visible in both the control and sept7b morphant cilia (arrowheads). Scale bars: 1 µm (A–C); 10 µm (D,E); 140 nm (F,G).