Fig. 2.

Dysregulated ANGPT2, IL-2RA and TNFR2 levels in myositis patients

(A) Serum angiopoietin-2 (ANGPT2) levels are higher in myositis patients with an elevated type I IFN signature score (IFN-hi) than in those without an elevated IFN signature (IFN-lo) and HCs. The y-axis represents the log₂-transformed serum level of ANGPT2 (ng/ml). (B) Myositis patients with ANGPT2 levels higher than the median value (>5.4 ng/ml) show significantly lower MMT-8 scores than those patients with ANGPT2 levels less than the median value (≤5.4 ng/ml). (C) IFN-hi patients show significantly higher soluble IL-2 receptor (IL-2RA) levels than IFN-lo patients and HCs. The y-axis represents the log₂-transformed serum levels of IL-2RA (pg/ml). (D) IFN-hi patients with IL-2RA levels higher than the upper limit of the normal range (2970 pg/ml) had significantly lower MMT-8 levels than IFN-lo patients with IL-2RA levels within the normal range. (E) Higher TNFR2 levels in IFN-hi patients than in IFN-lo patients and HCs. The y-axis represents the log₂-transformed serum levels of TNFR2 (ng/ml). (F) IFN-hi patients with TNFR2 levels higher than the upper limit of the normal range (11 ng/ml) had significantly lower MMT-8 levels than IFN-lo patients with TNFR2 levels within the normal range.