Fig. 3.

Effects of sifalimumab administration on serum protein levels in myositis patients

Eleven proteins had significantly reduced levels at day 98 after administration of sifalimumab in comparison with pre-treatment by paired t-test (BH P < 0.05). Percentage of change at day 98 relative to pre-treatment was scaled to have a mean of 0 and a s.d. of 1 for each protein across sifalimumab-administered patients. The black bar on the top denotes IFN-lo patients. The yellow bar shows four IFN-hi patients with ≤20% IFN target neutralization rate in blood. The blue bar denotes 20 IFN-hi patients with >20% IFN target neutralization rate in blood and two IFN-hi patients with >20% IFN neutralization rate in muscle (missing blood data). The normalized value of protein change at day 98 was used to order 11 proteins by the complete hierarchical clustering method.