TABLE. Main features of the plasmid-mediated quinolone resistance-harbouring enterobacteria isolated in this study.
| Species | Isolate | City | Hospital | qnrB-like allele | aac(6’)-Ib / aac(6’)-Ib-cr | ESBL genes | Phylogenetic group/clone | ST | MIC (µg/mL) | ||||||
| NAL | CIP | LEV | GAT | GEN | TOB | AMK | |||||||||
| Klebisella pneumoniae | CM4 | CAB | H6 | qnrB2 | -/+ | bla CTX-M-15 | NC/Kp1 | ST11 | > 512 | > 64 | 32 | 16 | 32 | 4 | 4 |
| CL4 | CAB | H1 | qnrB2 | -/+ | bla CTX-M-15 | NC/Kp1 | ST11 | > 512 | > 64 | > 64 | 64 | > 64 | 16 | 4 | |
| I3 | SF | H5 | - | -/+ | bla CTX-M-15 | NC/Kp1 | ST11 | > 512 | > 64 | 16 | 16 | > 64 | 32 | 4 | |
| I4 | SF | H5 | - | -/+ | bla CTX-M-15 | NC/Kp1 | ST11 | > 512 | > 64 | 16 | 16 | 64 | 16 | 4 | |
| CL6 | CAB | H1 | qnrB2 | -/+ | bla CTX-M-15 | NC/Kp2 | ST11 | > 512 | > 64 | 16 | 8 | 1 | 16 | 4 | |
| CL9 | CAB | H1 | qnrB1 | -/+ | bla CTX-M-15 | NC/Kp3 | ST48 | 64 | 4 | 1 | 2 | 32 | 16 | 2 | |
| T8 | CH | H10 | - | -/+ | bla CTX-M-15 | NC/Kp4 | ST11 | > 512 | 64 | 32 | 16 | 64 | 32 | 4 | |
| CV1 | CAB | H7 | qnrB19 | +/+ | bla CTX-M-15/ bla CTX-M-2 | NC/Kp5 | ST11 | > 512 | > 64 | 64 | 32 | > 64 | 64 | 32 | |
| L5 | CAB | H3 | qnrB19 | -/- | bla CTX-M-15 | NC/ND | ST392 | > 512 | > 64 | 4 | 4 | 2 | 16 | 8 | |
| B4 | CAB | H4 | qnrB2 | -/- | bla CTX-M-15 | NC/ND | ST11 | > 512 | 64 | > 64 | 64 | 0.5 | 1 | 1 | |
| CV2 | CAB | H7 | - | -/+ | bla CTX-M-2 | NC/ND | ST15 | > 512 | 64 | 8 | 4 | < 0.5 | 4 | 4 | |
| CM1 | CAB | H6 | qnrB19 | -/+ | bla CTX-M-2 | NC/ND | ST11 | > 512 | > 64 | 64 | 32 | > 64 | > 64 | > 256 | |
| B5 | CAB | H4 | qnrB19 | -/- | bla CTX-M-2 | NC/ND | ST11 | > 512 | 64 | 64 | 64 | > 64 | > 64 | > 256 | |
| CL7 | CAB | H1 | - | -/+ | bla CTX-M-2 | NC/ND | ST11 | > 512 | > 64 | 16 | 16 | 1 | 8 | 8 | |
| M2 | CAB | H7 | qnrB19 | -/- | bla CTX-M-2 | NC/ND | ST11 | > 512 | > 64 | > 64 | 64 | 2 | 16 | > 256 | |
| CL5 | CAB | H1 | - | -/+ | bla CTX-M-8 | NC/ND | ST14 | 64 | 8 | 2 | 4 | 1 | 16 | 8 | |
| Escherichia coli | L4 | CAB | H3 | - | -/+ | bla CTX-M-15 | B2/EC1a | ST131 | > 512 | > 64 | 16 | 16 | 1 | 16 | 8 |
| T1 | CH | H10 | - | -/+ | bla CTX-M-15 | B2/EC1a | ST131 | > 512 | > 64 | 64 | 16 | > 64 | > 64 | 16 | |
| CM2 | CAB | H6 | - | -/+ | bla CTX-M-15 | B2/EC1b | ST131 | > 512 | > 64 | 8 | 8 | > 64 | 32 | 8 | |
| T3 | CH | H10 | - | -/+ | bla CTX-M-15 | B2/EC1b | ST131 | > 512 | 64 | 32 | 8 | 1 | 1 | 2 | |
| SM5 | BA | H2 | - | -/+ | bla CTX-M-15 | B2/EC1c | ST131 | 512 | 2 | 1 | 0.5 | 2 | 16 | 4 | |
| M1 | CAB | H7 | - | -/+ | bla CTX-M-15 | A/EC2 | ST410 | > 512 | > 64 | 32 | 16 | > 64 | 64 | 32 | |
| SM4 | BA | H2 | - | -/+ | bla CTX-M-15 | A/EC3 | ST167 | > 512 | > 64 | 64 | 32 | 2 | 16 | 16 | |
| T2 | CH | H10 | qnrB6 | -/+ | bla CTX-M-2 | B1/EC4 | ST297 | > 512 | > 64 | > 64 | > 64 | 2 | 32 | 4 | |
| SM7 | BA | H2 | qnrB2 | -/+ | bla CTX-M-14 | D/EC5 | ST68 | > 512 | > 64 | > 64 | 32 | 1 | 1 | 4 | |
| SM8 | BA | H2 | qnrB2 | -/- | bla CTX-M-14 | D/EC5 | ST68 | > 512 | > 64 | 64 | 32 | < 0.5 | 0.5 | 0,5 | |
| Klebsiella oxytoca | C1 | SF | H9 | - | -/+ | bla CTX-M-2 | NC/ND | ND | 128 | 2 | 4 | 2 | 8 | 16 | 2 |
| T4 | CH | H10 | qnrB10 | -/- | bla CTX-M-2 | NC/ND | ND | > 512 | 64 | 32 | 16 | > 64 | > 64 | 16 | |
| Proteus mirabilis | SM6 | BA | H2 | qnrB2 | -/- | bla CTX-M-2 | NC/ND | ND | > 512 | > 64 | > 64 | 64 | 32 | 8 | 4 |
| CX2 | BA | H8 | qnrB10 | -/- | bla CTX-M-2 | NC/ND | ND | 128 | 2 | 4 | 2 | 8 | 16 | 32 | |
| T12 | CH | H10 | qnrB19 | -/- | bla CTX-M-2 | NC/ND | ND | > 512 | 32 | 8 | 32 | 64 | 32 | 4 | |
| Providencia sp. | CL2 | CAB | H1 | qnrB2 | -/- | bla CTX-M-2 | NC/ND | ND | > 512 | > 64 | > 64 | > 64 | > 64 | 64 | 1 |
| Enterobacter cloacae | CX1 | BA | H8 | qnrB10 | -/- | bla PER-2/ bla SHV-12 | NC/ND | ND | 128 | 2 | 4 | 2 | 8 | 16 | 4 |
AMK: amikacin; BA: Buenos Aires; CAB: Ciudad Autónoma de Buenos Aires; CH: Chubut; CIP: ciprofloxacin; ESBL: extended-spectrum β-lactamases; GAT: gatifloxacin; GEN: gentamicin; H1: Hospital de Clínicas, Universidad de Buenos Aires; H2: Corporación médica San Martín; H3: Hospital Alemán; H4: Hospital Británico; H5: Hospital Iturraspe; H6: CEMIC; H7: Sanatorio Mater Dei; H8: Hospital Eva Perón; H9: Hospital Cullen; H10: Hospital de Trelew; LEV: levofloxacin; MIC: minimum inhibitory concentration; NAL: nalidixic acid; NC: not correspond; ND: not determined; SF: Santa Fe; TOB: tobramycin.