Table 3.

Etiologies of Death: Vascular Versus Nonvascular in Longer-Term Follow-Up Trials

Trial	Etiology	Combination # of Deaths	Aspirin Alone # of Deaths	OR (95% CI)
SPS31	Vascular	72*	45*	1.61 (1.11–2.36)
	Nonvascular	41	32	1.28 (0.80–2.04)
CHARISMA10	Vascular	238	229	1.04 (0.87–1.25)
	Nonvascular	133	145	0.92 (0.72–1.16)
CURE11	Vascular	318	345	0.92 (0.79–1.08)
	Nonvascular	41	45	0.92 (0.60–1.40)
ACTIVE A12	Vascular	600	599	1.01 (0.89–1.14)
	Nonvascular	225	242	0.93 (0.77–1.12)
CASCADE13	Vascular	0	1	0.33† (0.01–8.36)
	Nonvascular	0	0	1.02† (0.02–52)
CREDO14	Vascular	NR	NR
	Nonvascular	NR	NR
REAL-LATE/ZEST-LATE15	Vascular	13‡	8‡	1.62 (0.67–3.91)
	Nonvascular	7	5	1.39 (0.44–4.39)
CASPAR16	Vascular	NR	NR
	Nonvascular	NR	NR
All longer-term trials	Vascular	1241	1227	1.05 (0.91–1.20)
	Excluding SPS3	1169	1182	0.99 (0.91–1.08)
	Nonvascular	447	469	0.95 (0.83–1.09)

NR indicates not reported.

^*Vascular includes probable vascular and unknown causes.

^†Estimated by adding 0.5 to each cell.

^‡Cardiac causes assumed to be vascular.