Table 4.

Effect of Clopidogrel Added to Aspirin on Fatal Hemorrhage in Longer-Term Follow-Up Trials

Trial	Combination # of Events	Aspirin Alone # of Events	OR (95% CI)
SPS31	NR	NR	⋯
CHARISMA10	26	17	1.53 (0.83–2.82)
CURE11	11	15	0.74 (0.34–1.61)
ACTIVE A12	42	27	1.57 (0.96–2.55)
CASCADE13	0	0	1.02* (0.02–52)
CREDO14	NR	NR	⋯
REAL LATE-ZEST LATE15	NR	NR	⋯
CASPAR16	2	1	2.01 (0.18–22)
All longer-term trials	81	60	1.35 (0.97–1.90)

NR indicates not reported.

^*Estimated by adding 0.5 to each cell.