Table 5.
Effect of Clopidogrel Added to Aspirin on Myocardial Infarction in Longer-Term Follow-Up Trials
| Trial | Combination # of MIs |
Aspirin Alone # of MIs |
OR (95% CI) |
|---|---|---|---|
| SPS31 | 30 | 38 | 0.78 (0.48 –1.26) |
| CHARISMA*10 | 185 | 197 | 0.94 (0.77–1.15) |
| CURE11 | 324 | 419 | 0.77 (0.66–0.89) |
| ACTIVE A12 | 90 | 115 | 0.78 (0.59–1.03) |
| CASCADE13 | 4 | 1 | 4.31 (0.47–40) |
| CREDO14 | 70 | 90 | 0.77 (0.56–1.07) |
| REAL LATE-ZEST LATE15 | 10 | 7 | 1.42 (0.54–3.74) |
| CASPAR†16 | NR | NR | |
| All longer-term Trials | 713 | 867 | 0.82 (0.74–0.91) |
MI indicates myocardial infarction; NR, not reported.
*
Only nonfatal MIs reported in the main results article; all MIs estimated from Table 3 in the Berger PB, et al. (6).
†
Hazard ratio reported: combination vs aspirin alone: HR, 0.81; 95% CI, 0.32–2.06; P=0.66.