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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Brain Res. 2013 Dec 16;1547:1–15. doi: 10.1016/j.brainres.2013.12.012

Figure 7.

Figure 7

Time course of Kv2.1-IR declustering of gastrocnemius motoneuron somas following tibial nerve ligation at key time points (20 minutes, 3 days, 8 days, 2 weeks, 4 weeks, and 6 months). Kv2.1-IR clusters are reduced in number but return to pre-injury size 6 months following injury without reinnervation. All comparisons are made to sham surgery control animals analyzed at 3 day, 8 day and 4 weeks following surgery. No significant differences were found between or within time points for the ipsilateral and contralateral sides in sham surgery control animals. Data is presented as mean ± SEM. Significance (p<0.05) was determined with pairwise ANOVA. (A) Kv2.1 areas are significantly reduced (indicated by single asterisk) at 3 days, 8 days, 2 weeks, and 4 weeks following injury. There are small, yet significant (indicated by double asterisk), decreases on the injury spared contralateral side of the rat spinal cord at 2 weeks and 4 weeks post injury. (B) The number of Kv2.1-IR macroclusters decrease significantly (indicated with asterisk) 3 days following tibial nerve crush and are significantly reduced at all following time points.