Figure 10.
Examination of hematoxylin and eosin staining in the UUO of nude mouse model (magnification of 400×). In the interstitial injury score, the nude mice exhibited increased the score in the left kidney compared with the control right kidney (from 1.50 ± 0.43 to 8.17 ± 0.31), and FTY720 and DMS pretreatment significantly decreased the scores (FTY720: from 8.17 ± 0.31 to 4.83 ± 0.31, DMS: from 8.17 ± 0.31 to 4.0 ± 0.26). N = 6. Data are presented as means ± SE. *P < 0.05. UUO, unilateral ureteral obstruction; DMS, N,N‐dimethylsphingosine.