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. 2013 Dec 19;1(7):e00182. doi: 10.1002/phy2.182

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© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effects of Ru360 (2 μmol/L) and CGP37157 (3 μmol/L) given in combination (Ru/CGP) on [Ca²⁺]_c and secretion transients elicited by repeated cell challenging with ACh. Experimental conditions and stimulation with ACh were as in Figure 1, except for the fact here Ru/CGP was cell‐perifused since 1 min before P5 to 1 min after P8 (top horizontal bars in each panel). (A) Example record of the [Ca²⁺]_c transients elicited by ACh in a fura‐2‐loaded BCC; inset shows the transients generated by the ACh pulses P4 and P5 at an expanded time scale. (B) Pooled averaged data on the normalized peak [Ca²⁺]_c amplitude. (C) Example catecholamine release responses (in nA, ordinate) obtained from a BCC batch; inset shows the transients elicited by ACh pulses P4 and P5 at an expanded time scale. (D) Averaged data from the secretion responses obtained using the protocols of panel (C). Data in (B and D) are means ± SEM of the number of single cells ([Ca²⁺]_c) and cell batches (secretion) from three different cultures, shown in parentheses. *P <0.05, **P <0.01 with respect to P4.